Anti-E2F-1 Monoclonal Antibody  

品牌：solarbio | 货号：K000152M

英文名称	Anti-E2F-1 Monoclonal Antibody
宿主	Mouse
别名	E2F-1;RBAP1;RBBP3;RBP3
应用	WB IF IP
稀释比例	WB 1:500. ICC 1:100.
交叉反应	Human Rat
蛋白分子量	70kDa
Gene ID	1869
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG2b
免疫原	Purified recombinant human E2F-1 protein fragments expressed in E.coli.
性状	液体
Public Immunogen Range	Purified recombinant human E2F-1 protein fragments expressed in E.coli.
Subcellular Locations	Nucleus
Swiss Prot	Q01094
克隆号	4G8-2C2-C12
克隆类型	Monoclonal Antibody
背景资料	The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.